Tag Archives: insulin-like growth factor

xxx I. Trapina, S. Plavina, N. Krasņevska, J. Paramonovs, D. Kairisa and N. Paramonova
IGF1 and IGF2 gene polymorphisms are associated with the feed efficiency of fattened lambs in Latvian sheep breads
Abstract |
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IGF1 and IGF2 gene polymorphisms are associated with the feed efficiency of fattened lambs in Latvian sheep breads

I. Trapina¹*, S. Plavina¹, N. Krasņevska¹, J. Paramonovs¹, D. Kairisa² and N. Paramonova¹

¹Genomics and Bioinformatics, Institute of Biology of the University of Latvia, Jelgava str. 3, LV-1004, Riga, Latvia
²Institute of Agrobiotechnology, Faculty of Agriculture, Latvian University of Life Sciences and Technologies, Liela Street 2, LV-3001, Jelgava, Latvia
*Correspondence: ilva.trapina@lu.lv

Abstract:

Feed efficiency is an economically important indicator in sheep farming. The most effective technology for selecting the best feed-efficient lambs for breeding is marker association selection of genetic variations in the sheep genome as potential biomarkers. In tissue growth and differentiation, insulin-like growth factors (IGFs) play a major role: IGF1 mediates the effects of growth hormone, and IGF2 is a growth regulator, regulating skeletal muscle growth. The study aims to find possible molecular markers for feed efficiency indicators in IGF1 and IGF2 genes for Latvian sheep breeds. The exonic regions of the IGF1 and IGF2 genes were sequenced for the first time in the genomic DNA of 76 controlled, intensively fattened lambs, to search for possible genetic biomarkers. Seven polymorphic loci in the IGF1 gene and sixteen in the IGF2 gene were detected. Statistically significant associations of the IGF1 SNP rs600896367 were found with residual indicators: Residual feed intake, Residual weight gain (RWG), and Residual intake and body weight gain (RIG), and with feed efficiency and feed conversion ratio in the overall group of samples. Additionally, IGF2 SNPs New_7 and rs429576107 exhibited associations with RWG and RIG specifically in the Latvian dark-head sheep group. On average, effect of the IGF1 SNP on associated feed efficiency residuals is 3.9%, with the most pronounced impact observed in RFI. In contrast, the influence of IGF2 SNPs is comparatively lower. Our results indicate that rs600896367 and New7/rs429576107 are potential molecular markers for marker-assisted selection in sheep breeding for residual feed efficiency indicators.

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